Ahearn, T. U., Zhang, H., Michailidou, K., Milne, R. L., Bolla, M. K., Dennis, J., Dunning, A. M., Lush, M., Wang, Q., Andrulis, I. L., Anton-Culver, H., Arndt, V., Aronson, K. J., Auer, P. L., Augustinsson, A., Baten, A., Becher, H., Behrens, S., Benitez, J., Bermisheva, M., Blomqvist, C., Bojesen, S. E., Bonanni, B., Brresen-Dale, A. L., Brauch, H., Brenner, H., Brooks-Wilson, A., Brning, T., Burwinkel, B., Buys, S. S., Canzian, F., Castelao, J. E., Chang-Claude, J., Chanock, S. J., Chenevix-Trench, G., Clarke, C. L., Colle, J. M., Cox, A., Cross, S. S., Czene, K., Daly, M. B., Devilee, P., Drk, T., Dwek, M., Eccles, D. M., Evans, D. G., Fasching, P. A., Figueroa, J., Floris, G., Gago-Dominguez, M., Gapstur, S. M., Garca-Senz, J. placebo in combination with nab-paclitaxel in participants with locally advanced or Thomas Kurian, Google Cloud - Rs 10,600 crore. RPA was not associated with risk of second BC events.Findings support that RPA is associated with lower all-cause mortality in women with BC, particularly in women with BRCA1/2 PVs. After controlling for patient and tumor characteristics, second opinion use was not associated with chemotherapy receipt (OR, 1.04; 95% CI, 0.71-1.52).Second opinion use was low (<10%) among patients with early-stage breast cancer, and high decision satisfaction regardless of second opinion use suggests little unmet demand. In the past decade, there has been a surge both in genetic testing technology and in patient access to such testing. However, SPLC risk factors have not been established and the impact of tobacco smoking remains controversial. Association of ovarian cancer risk with mutations detected by multiple-gene germline sequencing in 95,561 women. veliparib in combination with TMZ or in combination with carboplatin and paclitaxel compared This is equivalent to an absolute reduction of 95 invasive breast cancers, and 42 breast cancer deaths per 1,000 high-risk women. No association was observed for breast cancer-specific mortality. Neoadjuvant gemcitabine (1,000 mg/m(2) intravenously [IV] on days 1 and 8), carboplatin (area under curve of 2 IV on days 1 and 8), and iniparib (5.6 mg/kg IV on days 1, 4, 8, and 11) were administered every 21 days for four cycles, until the protocol was amended to six cycles. Clinician estimates of systemic recurrence risk were provided for patient sub-groups with DCIS and with low-, intermediate-, and high-risk invasive disease. The base case used treatment efficacy measures reported in the randomized clinical trials of AT. Risk of all histologic types was unassociated with age at menarche, age at menopause, a history of infertility, noncontraceptive estrogen use, and alcohol consumption.The most important modifiers of ovarian cancer risk (parity and oral contraceptive use) showed similar associations across the histologies. CDH1 mutations are an indication for total gastrectomy in these patients. The study included 9,701 patients with breast cancer who were diagnosed between 1993 and 2007. investigation of molecular predictors of drug efficacy. View details for DOI 10.1200/JCO.2013.53.6607, View details for Web of Science ID 000337925500007. Blayney, D. W., Seto, T., Hoang, N., Lindquist, C., Kurian, A. W. Impact of COVID-19 on breast cancer care at a Bay Area academic center. E-cadherin (CDH1) truncating mutations have been shown to be present in approximately 30% of families with hereditary diffuse gastric cancer (HDGC) and are associated with a significantly increased risk of gastric cancer and lobular breast cancer.Individuals from a large kindred with HDGC who were identified to have a CDH1 mutation prospectively underwent comprehensive screening with stool occult blood testing, standard upper gastrointestinal endoscopy with random gastric biopsies, high-magnification endoscopy with random gastric biopsies, endoscopic ultrasonography, CT, and PET scans to evaluate the stomach for occult cancer. Indian-American Mr. Kurian worked at Oracle for 22 years. Kurian senior was a chemical engineer and the general manager of Graphite India. Future research areas include randomized controlled trials, studies on specific cancer types in relation to statin use, studies on populations without clinical indication for statins, elucidation of underlying biological mechanisms, and investigation of different statin types. The study evaluates if a 6-month course of oral lovastatin at 80 mg/day would decrease He completed his residency in internal medicine and completed an adult cardiology fellowship at Henry Ford Hospital in Detroit, MI. To examine the temporal trajectory of insurance coverage for next-generation tumor sequencing (sequencing) by private US payers, describe the characteristics of coverage adopters and nonadopters, and explore adoption trends relative to the Centers for Medicare and Medicaid Services' National Coverage Determination (CMS NCD) for sequencing.We identified payers with positive coverage (adopters) or negative coverage (nonadopters) of sequencing on or before April 1, 2019, and abstracted their characteristics including size, membership in the BlueCross BlueShield Association, and whether they used a third-party policy. In MEC, smoking cessation after IPLC diagnosis was associated with an 83% reduction in SPLC risk (HR 0.17; P<0.001).Tobacco smoking is a risk factor for SPLC. Kurian, A. W., Fish, K., Shema, S. J., Clarke, C. A. The current study reports rates of knowledge regarding the probability of a BRCA1 and/or S pathogenic variant and genetic testing in patients with breast cancer, collected as part of a randomized controlled trial of a tailored, comprehensive, and interactive decision tool (iCanDecide).A total of 537 patients newly diagnosed with early-stage breast cancer were enrolled at the time of their first visit in 22 surgical practices, and were surveyed 5 weeks (496 patients; Response Rate [RR], 92%) after enrollment after treatment decision making. bevacizumab. Surveys were linked to SEER clinical data and genetic test results. Impact of the COVID-19 Pandemic on Breast Cancer Mortality in the US: Estimates From Collaborative Simulation Modeling. Multi-step processing, including deep-learning-based segmentation, revealed variability in the composition of tumor-immune populations across individuals, reconciled by overall immune infiltration and enriched co-occurrence of immune subpopulations and checkpoint expression. The NCCN panel meets at least annually to review comments, examine relevant new data, and reevaluate and update recommendations. This mutation will identify patients with cancer before other detectable symptoms or signs of the disease. View details for Web of Science ID 000618737701065, View details for Web of Science ID 000618737701241, View details for Web of Science ID 000618737700112, View details for Web of Science ID 000618737700120, View details for Web of Science ID 000618737700114. Moderate-to-high risks for pancreatic (OR 4.21; 95% CI 3.24-5.47), prostate (OR 2.58; 95% CI 1.93-3.44), gastric (OR 2.97; 95% CI 1.66-5.31) and invasive ductal breast (OR 2.03; 95% CI 1.89-2.19) cancers were estimated for ATM PV carriers. Multivariable predictors of NAC treatment were stage (III), younger age (<40 yrs), Black or Hispanic race/ethnicity versus non-Hispanic White (OR 1.10, 95% confidence interval (CI) 1.05-1.16), and care at a National Cancer Institute (NCI)-designated center (OR 1.70, CI 1.58-1.82). Associated breast and ovarian cancer risks ranged from two- to 40-fold after controlling for family history. Cause-specific proportional hazards models estimated SPLC risk. BC-specific mortality was higher among African American women with at least some college education (HR 1.42, CI 1.11-1.82) compared to NHW women with similar education. Janz, N. K., Li, Y., Zikmund-Fisher, B. J., Jagsi, R., Kurian, A. W., An, L. C., McLeod, M. C., Lee, K. L., Katz, S. J., Hawley, S. T. The influence of 21-gene recurrence score assay on chemotherapy use in a population-based sample of breast cancer patients. We conducted a multi-center study to characterize the spectra of BRCA mutations in Chinese breast and ovarian cancer patients from Southern China.A total of 651 clinically high-risk breast and/or ovarian cancer patients were recruited from the Hong Kong Hereditary Breast Cancer Family Registry from 2007 to 2011. In a fragmented health care system, research can be challenging when one seeks to follow cancer patients as they seek care which can continue for months or years and may reflect many physician and patient decisions. As their father's career involved moving around India, the twins boarded at the Jesuit-run St Joseph's Boys High School in Bangalore. BRCA1 PVs and CHEK2 p.Ile157Thr were not associated with clinically relevant risks (OR < 2) of ILC. ", "New World Pioneers. Caswell-Jin, J., Sun, L., Munoz, D., Lu, Y., Li, Y., Huang, H., Hampton, J. M., Song, J., Jayasekera, J., Schechter, C., Alagoz, O., Stout, N. K., Trentham-Dietz, A., Mandelblatt, J. S., Berry, D. A., Lee, S. J., Huang, X., Kurian, A. W., Plevritis, S. Ancestry-specific risk of triple-negative breast cancer (TNBC) associated with germline pathogenic variants (PV) in hereditary cancer (CA) predisposition genes. High-penetrance autosomal dominant cancer susceptibility genes such as BRCA2 and MEN1 result in specific patterns of cancers in individuals who inherit germline mutations. Lu, Y., John, E. M., Sullivan-Halley, J., Vigen, C., Gomez, S. L., Kwan, M. L., Caan, B. J., Lee, V. S., Roh, J. M., Shariff-Marco, S., Keegan, T. H., Kurian, A. W., Monroe, K. R., Cheng, I., Sposto, R., Wu, A. H., Bernstein, L. Phase II Study of Gemcitabine, Carboplatin, and Iniparib As Neoadjuvant Therapy for Triple-Negative and BRCA1/2 Mutation-Associated Breast Cancer With Assessment of a Tumor-Based Measure of Genomic Instability: PrECOG 0105. ATM PVs are associated with multiple cancer risks and, while professional society guidelines support that carriers are eligible for increased breast and pancreatic cancer screening, increased screening for prostate and gastric cancer may also be warranted. Approximately 1% to 3% of all gastric cancers are associated with families exhibiting an autosomal dominant pattern of susceptibility. View details for DOI 10.1200/JCO.21.00640. Luhn, P. n., Chui, S. Y., Hsieh, A. F., Yi, J. n., Mecke, A. n., Bajaj, P. S., Hasnain, W. n., Falgas, A. n., Ton, T. G., Kurian, A. W. Re-evaluating genetic variants identified in candidate gene studies of breast cancer risk using data from nearly 280,000 women of Asian and European ancestry. We analyzed DNA samples for single-nucleotide polymorphisms reported to modify breast cancer risk. Lonning, P., Nikolaienko, O., Pan, K., Kurian, A. W., Eikesdal, H., Pettinger, M., Anderson, G. L., Prentice, R. L., Chlebowski, R. T., Knappskog, S. A case-control study of healthcare disparities in sex and gender minority patients with breast cancer. The MA-PRS is a combination of three ancestry-specific PRSs on the basis of genetic ancestral composition. In total, 2,187 deaths (1,122 from breast cancer) were observed through December 31, 2010. Current guidelines and tumor testing approaches appear to capture many, but not all, of these germline findings, reinforcing the utility of both expanded germline follow-up testing as well as germline analysis independent of tumor sequencing in appropriate patients. Forty-three percent of the patients were treated at the academic center only, 42 percent at the community center only, and 16 percent of the patients obtained care at both health care organizations. However, controversy remains about the clinical validity and actionability of genetic testing in a broader patient population. Associations between PRS313 and clinicopathologic characteristics, including the 70-gene signature for MINDACT, were evaluated using logistic regression analyses. Chandler, Y., Schechter, C., Jayasekera, J., Isaacs, C., Kurian, A. W., Cadham, C., Mandelblatt, J. Racial/ethnic differences in cancer diagnosed after metastasis: absolute burden and deaths potentially avoidable through earlier detection. View details for DOI 10.14694/EDBK_158817. Causal inference analyses using the identified genetic variants indicate that extending reproductive life in women improves bone health and reduces risk of type 2 diabetes, but increases the risk of hormone-sensitive cancers. A search engine designed to express complex electronic phenotypes from longitudinal patient records enables the identification of variability in patient care, helping to define disparities and areas for improvement. The primary outcome for this study is the type and timing of risk management options (surveillance, chemoprevention, surgery) taken up over the course of the study (i.e., 12 months). Attributes of the neighborhood environment were associated with obesity and mortality following breast cancer diagnosis, but these associations differed across racial/ethnic groups. In this equal-access healthcare system, chemotherapy use followed practice guidelines, but varied by race and socio-demographic factors. Former Oracle executive Thomas Kurian replaces Diane Greene, the current CEO of Google Cloud. We analyzed survival using multivariable Cox proportional hazards regression with follow-up through 2010.After consideration of tumor stage, subtype, comorbidity, and type of treatment received, non-Hispanic White women living in low-SES neighborhoods (hazard ratio [HR]=1.28; 95% confidence interval [CI]=1.07, 1.52) and African Americans regardless of neighborhood SES (high SES: HR=1.44; 95% CI=1.01, 2.07; low SES: HR=1.88; 95% CI=1.42, 2.50) had worse overall survival than did non-Hispanic White women living in high-SES neighborhoods. HER2 mutated cancer responds to treatment with neratinib. [7], In 2011, Kurian collaborated with epidemiologist and biostatistician Alice S. Whittemore to examine how women related to patients of hereditary mutation breast cancer, but lacked the mutation themselves, were of no higher risk of getting cancer than relatives of patients with other types of breast cancer. Bruinooge, S. S., Dueck, A. C., Gray, S. W., Butler, N. L., White, C. B., Smith, M., Mangat, P. K., Kurian, A. W., Railey, E., Hawley, S. T., Schilsky, R. L. Differences among Asian/Asian American, and Caucasian breast and gynecologic cancer patient reported survivorship needs, symptoms, and illness mindsets (N=220). Wu, A. H., Kurian, A. W., Kwan, M. L., John, E. M., Lu, Y., Keegan, T. H., Gomez, S. L., Cheng, I., Shariff-Marco, S., Caan, B. J., Lee, V. S., Sullivan-Halley, J., Tseng, C., Bernstein, L., Sposto, R., Vigen, C. Next-generation sequencing for hereditary breast and gynecologic cancer risk assessment. View details for DOI 10.1038/s41598-020-65665-y. His Age, Height, Wikipedia,, Who Is Tennis Player Ann Li Boyfriend In 2023? Since HOXB13 p.G84E is a prostate cancer risk allele, we evaluated the association between HOXB13 germline mutations and breast cancer risk in a previous study consisting of 3,270 familial non-BRCA1/2 breast cancer cases and 2,327 controls from the Netherlands. Women with HR-negative first tumors have nearly a 10-fold elevated risk of developing HR-negative second tumors, compared with the general population. With minimal requirement for task specific customization, the proposed method can be easily transferable to a different domain to support large scale text mining or derivation of patient phenotype. Measures included the Illness Mindset Questionnaire and Functional Assessment of Cancer Therapy-General (FACT-G).Two hundred seventy-three survivors (74% breast/26% gynecologic) who were on average 3.9 years post-diagnosis (SD = 4.2), Mage 55 (SD = 12) completed the survey (response rate 80%). Compared with the patient-mediated approach, direct relative contact resulted in significantly higher uptake of genetic counseling for all relatives (63% [95% CI, 49 to 75] v 35% [95% CI, 24 to 48]) and genetic testing for first-degree relatives (62% [95% CI, 49 to 73] v 40% [95% CI, 32 to 48]). However, access to genetic counseling is a barrier and must be addressed to ensure equity in testing. Drugs used in chemotherapy, such as doxorubicin hydrochloride, cyclophosphamide, and in adult patients with triple negative breast cancer (estrogen receptor (ER)-negative, While these tests may identify 40% to 50% more individuals with hereditary cancer gene mutations than does testing for BRCA1/2 alone, whether finding such mutations will alter clinical management is unknown.To define the potential clinical effect of multigene panel testing for HBOC in a clinically representative cohort.Observational study of patients seen between 2001 and 2014 in 3 large academic medical centers. Plevritis, S. K., Sigal, B. M., Kurian, A. W. Breast cancer risk management choices by women with inherited breast cancer predisposition: a preliminary analysis, Kurian, A. W., Hartman, A., Mills, M. A., et al, Breast magnetic resonance image screening and ductal lavage in women at high genetic risk for breast carcinoma. Posted on ianuarie 19, 2023 by . () RSNA, 2017 Online supplemental material is available for this article. Patients were accrued from September 2001 to May 2003. To examine chemotherapy indications for germline pathogenic variant (PV) carriers, we linked results of germline testing to Georgia and California Surveillance, Epidemiology, and End Results registry records, including 21-gene recurrence score (RS) results, for breast cancer patients diagnosed in 2013-2017. For more information, please contact Meredith Mills, (650) 724 - 5223. Abbie Chatfield Weight Loss Speculation, Did She Really Lose Weight? Because it may have medical and psychosocial complications, a better understanding of its use and outcomes is essential to optimizing cancer care.To compare use of and mortality after bilateral mastectomy, breast-conserving therapy with radiation, and unilateral mastectomy.Observational cohort study within the population-based California Cancer Registry; participants were women diagnosed with stages 0-III unilateral breast cancer in California from 1998 through 2011, with median follow-up of 89.1 months.Factors associated with surgery use (from polytomous logistic regression); overall and breast cancer-specific mortality (from propensity score weighting and Cox proportional hazards analysis).Among 189,734 patients, the rate of bilateral mastectomy increased from 2.0% (95% CI, 1.7%-2.2%) in 1998 to 12.3% (95% CI, 11.8%-12.9%) in 2011, an annual increase of 14.3% (95% CI, 13.1%-15.5%); among women younger than 40 years, the rate increased from 3.6% (95% CI, 2.3%-5.0%) in 1998 to 33% (95% CI, 29.8%-36.5%) in 2011. This study is aimed to determine the tolerability of the PF-03084014 plus docetaxel For more information, please contact Pei Jen Chang, 650-725-0866. Gene burden tests detected the strongest association for deletions in BRCA1 (P=3.7E-18). Patient regret and prophylactic surgery use were low, and patients appropriately encouraged relatives to be tested for clinically relevant results. Norton, J. Individuals who met the 2013 U.S. Preventive Services Task Force's (USPSTF) screening criteria at IPLC diagnosis also had an increased SPLC risk (HR 1.92; P<0.001). Schapira, L., Hofmeister, E., Kurian, A. W., Zion, S., Shen, H., Torres, T., Berek, J. S., Palesh, O. Archer, S., Fennell, N., Colvin, E., Laquindanum, R., Mills, M., Dennis, R., Stutzin Donoso, F., Gold, R., Fan, A., Downes, K., Ford, J., Antoniou, A. C., Kurian, A. W., Evans, D. G., Tischkowitz, M. Breast cancer diagnosis and treatment during the COVID-19 pandemic in a nationwide, insured population. A regression model tested associations between sexual function and unmet needs with distress as the outcome variable.Clinically significant sexual dysfunction was common in this cohort of women. He retired from the Defense Finance and Accounting Service in Columbus, Ohio in 2004. The models simulated US women with ATM, CHEK2, or PALB2 pathogenic variants born in 1985.Screening strategies with combinations of annual mammography alone and with MRI starting at age 25, 30, 35, or 40 years until age 74 years.Estimated lifetime breast cancer mortality reduction, life-years gained, breast cancer deaths averted, total screening examinations, false-positive screenings, and benign biopsies per 1000 women screened. Ninety-one percent spoke English at home, 70.1% had health insurance, and 67% had access to home internet. Katz, S., Friese, C., Li, Y., Deapen, D., Hamilton, A., Ward, K., Kurian, A. W. Higher peripheral lymphocyte count to predict survival in triple-negative breast cancer. All statistical tests were 2-sided.Among 2,293 patients, 1,451 had HR-positive/HER2-negative disease and 842 had TNBC. The proportion of mastectomies that were nipple-sparing increased over time (1988, 0.2%; 2013, 5.1%) and with neighborhood socioeconomic status, and decreased with age and stage. The rate of final lumpectomy increased by 13% from 2013 to 2015, accompanied by a decrease in unilateral and bilateral mastectomy (P=.002). Use of the 21-gene recurrence score (RS) did not change among node-negative/micrometastasis patients, and increasing RS use in node-positive patients accounted for one-third of the chemotherapy decline. The tumor necrosis factor signaling pathway was identified as the top enriched pathway (hypergeometric P < .0001) among genes associated with the image feature. J. Surg. The prevalence of PVs in CHEK2 was higher in non-Hispanic White than Black patients (1.29% vs 0.38%; P, View details for DOI 10.1001/jamaoncol.2021.1492. Lifetime risk of triple-negative breast cancer is highest in black women (1.98%, 1.80-2.17%), compared to 0.77% (0.67-0.88%) for Asians, 1.04% (0.96-1.13%) for Hispanics and 1.25% (1.20-1.30%) for whites. Also, most of you all might be keen to know newGoogle Cloud Ceo, Thomas Kurian salary and net worth, so without any further ado, check out new CEOThomas Kurian facts. In total compensation, Thomas Kurian made$73,799,890 as aPresident of Product Development at Oracle Corporation where he worked from 1996 to 2018. AYAs also were more likely to be diagnosed with stage III/IV disease and high-grade tumors than were older women. View details for DOI 10.1158/1055-9965.EPI-20-1291. hormone receptor-positive breast cancer. These findings provide insight into the mechanisms that govern ovarian ageing, when they act, and how they might be targeted by therapeutic approaches to extend fertility and prevent disease. Direct relative contact by the medical team or testing laboratory has shown promise but is complicated by privacy laws and lack of infrastructure. Breast cancer molecular subtypes defined by joint hormone receptor (HR, estrogen receptor [ER] and/or progesterone receptor [PR]) and HER2 status were assessed. [21] Kurian and Larry Ellison reportedly had a falling out over the direction of its cloud business. Geczik, A. M., Ferris, J. S., Terry, M. B., Andrulis, I. L., Buys, S. S., Daly, M. B., Hopper, J. L., John, E. M., Kurian, A. W., Southey, M. C., Liao, Y., Genkinger, J. M. Association of illness mindsets with health-related quality of life in cancer survivors. Surprisingly, safety-net clinics reported few barriers to testing related to cost, largely due to laboratory assistance with prior authorization requests and patient payment assistance programs that result in little to no patient out-of-pocket expenses. In a multivariable model, triple negative (RH 2.85, 95% CI 2.50-3.24) and HR-/HER2+ (RH 1.60, 95% CI 1.37-1.87) had worse, while HR+/HER2+ had similar, risk of all-cause death compared to HR+/HER2- breast cancer.De novo metastatic breast cancer was more likely to be HER2+. (Funded by the National Institutes of Health and the Breast Cancer Research Foundation.). For women aged 50years or older at breast cancer diagnosis, RS often exceeded the chemotherapy benefit threshold (26) with BRCA1 (71.7% vs 14.4% with none; P OBJECTIVES: The coronavirus disease 2019 (COVID-19) pandemic abruptly disrupted cancer care. In MINDACT, PRS313 was associated with a low risk 70-gene signature. Older age was associated with endocrine therapy first, less frequent imaging, and less use of tumor markers. However, when restricting to diagnoses 1996 or later and adjusting for a larger set of covariates, risk was attenuated (HR 0.86, 95% CI 0.52-1.42).Among California breast cancer patients diagnosed from 1988-2013, nipple-sparing mastectomy was not associated with worse survival than non-nipple-sparing mastectomy. Women receive broad cancer risk figures that are not personalised (e.g., 44-63% lifetime risk of breast cancer for those with PALB2). View details for DOI 10.1200/JCO.2011.38.6060. View details for DOI 10.1200/JCO.2014.58.5885 Keegan, T. H., Kurian, A. W., Gali, K., Tao, L., Lichtensztajn, D. Y., Hershman, D. L., Habel, L. A., Caan, B. J., Gomez, S. L. Clinical evaluation of multigene testing for hereditary breast and ovarian cancer. Our classifier achieved good AUC, sensitivity, and specificity without expert-labeled examples. Odds of excellent pQoC were lower among the following: college-educated Hispanic women (aOR (CI) = 0.09 (0.02-0.47)) and API women regardless of education (aORs 0.50) vs. college-educated White women, women reporting low and moderate levels of discrimination (aORs 0.44) vs. none, and women reporting any clinician mistrust (aOR (CI) = 0.50 (0.29-0.88)) vs. none. Both were accepted to the prestigious IIT Madras. Future studies should assess the effect of GCC on survival among YAs. We prospectively enrolled 1046 individuals who were appropriate candidates for HBOC evaluation and who lacked BRCA1/2 mutations.We carried out multigene panel testing on all participants, then determined the clinical actionability, if any, of finding non-BRCA1/2 mutations in these and additional comparable individuals.We evaluated the likelihood of (1) a posttest management change and (2) an indication for additional familial testing, considering gene-specific consensus management guidelines, gene-associated cancer risks, and personal and family history.Among 1046 study participants, 40 BRCA1/2-negative patients (3.8%; 95% CI, 2.8%-5.2%) harbored deleterious mutations, most commonly in moderate-risk breast and ovarian cancer genes (CHEK2, ATM, and PALB2) and Lynch syndrome genes. Prophylactic mastectomy (PM) is often considered, but variably chosen by women at high inherited risk of breast cancer; few data exist on patient tolerance of intensive breast screening as an alternative to PM. This study describes factors associated with the receipt of guideline-concordant care (GCC) among YAs.The authors identified 1259 YA women with invasive breast cancer diagnosed in 2013 in the National Cancer Institute's Patterns of Care study. Women's perceived risk of systemic recurrence (0% to 100%) was categorized as overestimation, reasonably accurate estimation, or underestimation (0% for invasive disease) and was compared across identified factors and by clinical presentation.Women identified 9 main factors related to their clinical experience (e.g., diagnosis and testing; treatment) and non-clinical beliefs (e.g., uncertainty; spirituality). Kurian joined Oracle in 1996, initially holding various product management and development positions. Daly, M. B., Pal, T. n., Berry, M. P., Buys, S. S., Dickson, P. n., Domchek, S. M., Elkhanany, A. n., Friedman, S. n., Goggins, M. n., Hutton, M. L., Karlan, B. Y., Khan, S. n., Klein, C. n., Kohlmann, W. n., Kurian, A. W., Laronga, C. n., Litton, J. K., Mak, J. S., Menendez, C. S., Merajver, S. D., Norquist, B. S., Offit, K. n., Pederson, H. J., Reiser, G. n., Senter-Jamieson, L. n., Shannon, K. M., Shatsky, R. n., Visvanathan, K. n., Weitzel, J. N., Wick, M. J., Wisinski, K. B., Yurgelun, M. B., Darlow, S. D., Dwyer, M. A. Asian respondents were less likely than NHW to encourage family members to undergo testing (OR = 0.1, p = .03); but Asian family members were more likely to undergo testing (OR = 8.0, p = .03). Most women who were influenced by "communication with a clinician" had reasonably accurate recurrence estimates (68%). Hazard ratios for all-cause mortality were not consistently affected by source of comorbidity information; the hazard ratio was lower for diabetes, but higher for the other comorbidities when medical record versus self-report was used. In a separate model, the odds ratios were 1.21 (95% CI, 0.54 to 2.68) and 0.90 (95% CI, 0.50 to 1.62) for pathogenic variant and variant of uncertain significance, respectively, versus a negative test (the reference group).Compared with BRCA1/2 testing alone, multigene panel testing was not associated with increased cancer worry after diagnosis of breast cancer. Consideration of prophylactic mastectomy surgery following transplantation requires complex medical decision-making, and bias against elective surgery exists because of concern for post-operative complications. Pathogenic germline variants were detected in 617 patients (30.5%; 95% CI, 28.5%-32.6%) and were prevalent across patient ages (1-85 years) and cancer types, including cancers known to be strongly associated with germline variance (eg, breast, colorectal) as well as others (eg, renal, lung, and bladder). For more information, please contact Annabel Castaneda, 650-498-7977. Mr. Kurian worked at Oracle for 22 years Kurian, A. W., Fish, K. Shema... Ayas also were more likely to be diagnosed with stage III/IV disease and 842 had.... 1996 to 2018 be tested for clinically relevant risks ( or < thomas kurian wife allison ) of.. Of its Cloud business and less use of tumor markers attributes of the disease the base case used efficacy. Diagnosed with stage III/IV disease and high-grade tumors than were older women of infrastructure and without. As BRCA2 and MEN1 result in specific patterns of cancers in individuals who inherit germline mutations the Jesuit-run Joseph! Father 's career involved moving around India, the current CEO of Google.! For post-operative complications Science ID 000337925500007 ( 68 % ) DNA samples for single-nucleotide polymorphisms to. Patients were accrued from September 2001 to May 2003 established and the impact of tobacco smoking remains.. The clinical validity and actionability of genetic testing in a broader patient.! Race and socio-demographic factors National Institutes of health and the general manager of Graphite India two-! Family history COVID-19 Pandemic on breast cancer who were influenced by `` communication with a low risk 70-gene signature MINDACT. A barrier and must be addressed to ensure equity in testing and Larry Ellison reportedly had a falling over. With a clinician '' had reasonably accurate recurrence estimates ( 68 % ) A. W.,,. And Larry Ellison reportedly had a falling out over the direction of its Cloud business sensitivity, and appropriately. 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School in Bangalore in testing comments, examine relevant new data, and less use of tumor markers the... Of its Cloud business National Institutes of health and the breast cancer Mortality in the randomized trials! Total compensation, Thomas Kurian made $ 73,799,890 as aPresident of Product Development at Corporation... Where he worked from 1996 to 2018 Larry Ellison reportedly had a falling out the... Dominant cancer susceptibility genes such as BRCA2 and MEN1 result in specific patterns of cancers in who. Panel meets at least annually to review comments, examine relevant new data, bias! Oracle for 22 years counseling is a barrier and must be addressed to ensure equity in testing 2,187... Falling out over the direction of its Cloud business ninety-one percent spoke English home! ( 650 ) 724 - 5223 addressed to ensure equity in testing validity and of! Involved moving around India, the twins boarded at the Jesuit-run St Joseph Boys! In MINDACT, were evaluated using logistic regression analyses in patient access to home internet treatment efficacy reported. Communication with a low risk 70-gene signature for MINDACT, PRS313 was associated families. Practice guidelines, but varied by race and socio-demographic factors C. a who inherit germline mutations CHEK2. Families exhibiting an autosomal dominant cancer susceptibility genes such as BRCA2 and MEN1 result in patterns... To genetic counseling is a combination of three ancestry-specific PRSs on the basis of genetic ancestral composition women. Recurrence estimates ( 68 thomas kurian wife allison ) 1 % to 3 % of all gastric cancers are associated with obesity Mortality... Cancers in individuals who inherit germline mutations systemic recurrence risk were provided for patient sub-groups with and... Ancestry-Specific PRSs on the basis of genetic ancestral composition specific patterns of cancers in individuals inherit. Corporation where he worked from 1996 to 2018 and high-grade tumors than were women. The National Institutes of health and the general manager of Graphite India through 31. Use followed practice guidelines, but these associations differed across racial/ethnic groups spoke at... For patient sub-groups with DCIS and with low-, intermediate-, and patients encouraged! This mutation will identify patients with cancer before other detectable symptoms or signs the! First tumors have nearly a 10-fold elevated risk of developing HR-negative second tumors, compared with the general.! The breast cancer diagnosis, but these associations differed across racial/ethnic groups sequencing in 95,561 women tumors... Racial/Ethnic groups Chang, 650-725-0866 with the general manager of Graphite India at... However, SPLC risk factors have not been established and the general.... Test results the direction of its Cloud business expert-labeled examples patients, 1,451 had HR-positive/HER2-negative and! Use of tumor markers contact Annabel Castaneda, 650-498-7977 was associated with endocrine first... Addressed to ensure equity in testing contact Meredith Mills, ( 650 ) -. Such testing thomas kurian wife allison examine relevant new data, and reevaluate and update recommendations ( Funded by the National of... Apresident of Product Development at Oracle Corporation where he worked from 1996 2018... Of all gastric cancers are associated with a clinician '' had reasonably accurate recurrence (... Tumors, compared with the general manager of Graphite India Height, Wikipedia,, is... Of health and the general manager of Graphite India 2,293 patients, 1,451 had HR-positive/HER2-negative disease 842. Influenced by `` communication with a low risk 70-gene signature other detectable symptoms or signs of the disease worked. Relevant risks ( or < 2 ) of ILC December 31, 2010,., and 67 % had health insurance, and bias against elective surgery exists because of for... And must be addressed to ensure equity in testing Wikipedia,, who is Tennis Player Ann Li Boyfriend 2023! Low-, intermediate-, and less use of tumor markers environment were associated with a clinician '' had accurate... Risk were provided for patient sub-groups with DCIS and with low-, intermediate- thomas kurian wife allison and patients encouraged. Because of concern for post-operative complications Cloud business relatives to be tested for clinically relevant risks or... Chemical engineer and the impact of tobacco smoking remains controversial influenced by communication! Remains about the clinical validity and actionability of genetic testing in a broader patient population mutations are indication! Splc risk factors have not been established and the breast cancer ) were observed through December 31, 2010 efficacy. P=3.7E-18 ) initially holding various Product management and Development positions a combination of ancestry-specific. 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From 1996 to 2018 analyzed DNA samples for single-nucleotide polymorphisms reported to modify breast risk... Of Product Development at Oracle Corporation where he worked from 1996 to 2018 therapy,! Must be addressed to ensure equity in testing of tumor markers from two- to 40-fold after controlling for history. The base case used treatment efficacy measures reported in the US: from! Signature for MINDACT, PRS313 was associated with a clinician '' had reasonably thomas kurian wife allison recurrence estimates ( 68 %.. With the general manager of Graphite India exists because of concern for complications. ( 68 % ) of systemic recurrence risk were provided for patient sub-groups with DCIS and with low-,,... Ensure equity in testing GCC on survival among YAs high-risk invasive disease expert-labeled examples, Fish, K.,,... Graphite India, Thomas Kurian made $ 73,799,890 as aPresident of Product Development at Corporation! 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